Program

12.30 – 13.50

Registration – Posters mounting

13.50 – 14.00

Welcome words

14.00 – 15.40

Session 1: Clinical EPR / Melanin

 Chair: Bernard Gallez (Brussels, Belgium)

14.00 – 14.30

Plenary - Clinical EPR: early days, past, present, future

Harold M. Swartz (Hanover, USA)

14.30 – 14.50

Neuromelanins in brain aging, neurodegeneration and neuromelanin. Magnetic Resonance Imaging as biomarker in neurodegenerative and psychiatric disorders

Luigi Zecca (Segrate, Italy)

14.50 – 15.10

Meeting the challenge of tracking melanoma cells using clinical EPR and multiharmonic analysis

Mohammad Wehbi (Brussels, Belgium)

15.10 – 15.40

Plenary - EPR study of the structure and basic properties of melanin pigments

Tadeusz Sarna (Krakow, Poland)

15.40 – 16.10

Coffee break

16.10 – 17.20

Session 2: Site-directed spin labeling

 Chair: Martina Huber (Leiden, The Netherlands)

16.10 – 16.40

Plenary - Spin labels and EPR spectroscopy: A powerful association for macromolecules studies

Valérie Belle (Marseille, France)

16.40 – 17.00

Using the Noncanonical Metallo-Amino Acid [Cu(II)(2,2'-bipyridin-5-yl)]-alanine as Spin-Label to Study the Structures of Proteins

Leandro Tabares (Gif-sur-Yvette, France)

17.00 – 17.20

Calmodulin: a protein platform for developing DEER experiments

Marco Bortolus (Padova, Italy)

17.30 – 19.30

Welcome reception    

9.00 – 10.40

Session 3: Spin labels, spin traps, spin probes for EPR and DNP

 Chair: Micael Hardy (Marseille, France)

9.00 – 9.30

Educational - Probing the local environment with stable triarylmethyl (TAM) radicals: what can be measured and best practices

Benoit Driesschaert (Morgantown, USA)

9.30 – 10.00

Educational - Detection of peroxynitrite with the use of boronate probes - focus on free radical transient species

Adam Sikora (Lodz, Poland)

10.00 – 10.20

Metabolic soft spot identification in tetraethyl-substituted nitroxide probes

Fabienne Peyrot (Paris, France)

10.20 – 10.40

Signal enhanced ssNMR DNP using nitroxide biradicals: lighting the way

Olivier Ouari (Marseille, France)

10.40 – 11.20

Coffee break

11.20 – 12.40

Session 4: Spin labels, spin traps, spin probes for EPR and DNP (continued)

 Chair: Fabienne Peyrot (Paris, France)

11.20 – 11.40

Development of Triarylmethyl Radical Spin Probe for in vivo Detection of Reactive Oxygen Species (ROS) by Electron Paramagnetic Resonance

Misa Shaw (Morgantown, USA)

11.40– 12.00

CAR T cells loaded with iron oxide nanoparticles for MRI tracking of tumor infiltration and magnetic manipulation

Huan Chen (Paris, France)

12.00 – 12.20

Study of spin-spin interactions on a nanoparticle surface to design new EPR imaging probes

Pierre Ernotte (Mons, Belgium)

12.20 – 12.40

Design, synthesis and applications of superoxide probes

Micael Hardy (Marseille, France)

12.40 – 14.00

Lunch

14.00 – 15.30

Poster session

Odd numbers

15.30 – 16.00

Coffee break

16.00 – 17.20

Session 5: EPR on a chip

 Chair: Mark Tseytlin (Morgantown)

16.00 – 16.30

Plenary - Miniaturized EPR detection schemes towards pulse table top and in situ EPR applications

Alexander Schnegg (Mulheim, Germany)

16.30 – 16.50

Considerations for reaction and process monitoring using an EPR-on-a-chip sensor

Joseph McPeak (Berlin, Germany)

16.50 – 17.20

Plenary - Micro-resonators for Biological application of Electron Spin Resonance

Aharon Blank (Haifa, Israel)

9.00 – 10.40

Session 6: Macromolecules / Metal Proteins

 Chair: Sabine Van Doorslaer (Antwerpen, Belgium)

9.00 – 9.30

Educational - The use of DEER and RIDME for measuring nanometre distances in biomacromolecules

Janet Lovett (St Andrews, UK)

9.30 – 10.00

Educational - What can EPR tell about heme proteins?

Ines Garcia Rubio (Zaragoza, Spain)

10.00 – 10.20

Understanding the molecular basis of industrially relevant biocatalysts: an EPR investigation of chlorite dismutases

Ilenia Serra (Antwerp, Belgium)

10.20 – 10.40

Coffee break

10.40 – 12.10

Session 7: Macromolecules / Metal Proteins (continued)

 Chair: Valérie Belle (Marseille, France)

10.40 – 11.20

Plenary - EPR of intrinsically disordered proteins and membrane proteins

Martina Huber (Leiden, The Netherlands)

11.20 – 11.40

Mismetallation or regulation? Role of manganese ions in tuning the radical generation in ribonucleotide reductase

Shari Meichsner (Dortmund, Germany)

11.40 – 12.10

Assignment of early intermediate states of the Nitrogenase reaction by Se incorporation and regularization of EPR spectra

Erik Schleicher (Freiburg, Germany)

12.10 – 13.30

Lunch

13.30 – 15.00

Session 8: In vivo, Oximetry, Imaging

 Chair: Martyna Elas (Krakow, Poland)

13.30 – 14.00

 Plenary - EPR oximetry in vivo: Mice to Men

Periannan Kuppusamy (Hanover, USA)

14.00 – 14.20

LiNc-BuO-based microspheres for non-invasive oximetric imaging of glioblastoma tumors

Agnieszka Drzal (Krakow, Poland)

14.20 – 14.40

Characterization of the impact of an inhibitor of the mitochondrial pyruvate carrier (MPC) using in vivo EPR and CEST-MRI

Chloé Buyse (Brussels, Belgium)

14.40 – 15.00

Rabbit Tumor Oxygen Imaging Using Human-Size 9 mT pulse EPR Imager

Boris Epel (Chicago, USA)

15.00 – 15.30

Coffee break

15.30 – 15.45

Laudatio: Fellows of the International EPR Society 2023

Murali C. Krishna and Howard Halpern      

15.45 – 17.35

Session 9: In vivo, Oximetry, Imaging (continued)

 Chair: Howard Halpern (Chicago, USA)

15.45 – 16.15

Plenary – Molecular Imaging of the Tumor Microenvironment

Murali C. Krishna (Bethesda, USA)

16.15 – 16.35

Oxygen partial pressure dynamic as a marker of chemotherapy efficiency – in vivo study on OxyChip and murine pancreatic cancer

Martyna Krzykawska- Serda (Krakow, Poland)

16.35 – 17.05

In vivo Electron Paramagnetic Resonance profiling of tumor microenvironment upon tumor progression to malignancy in animal model of breast cancer

Valery Khramtsov (Morgantown, USA)

17.05 – 17.35

Plenary - Combining EPR and Ultrasound in cancer imaging and therapy

Martyna Elas (Krakow, Poland)

19.00 – 23.00

Conference dinner cruise         

8.30 – 10.30

Session 10: Oxidative stress

 Chair: Olivier Ouari (Marseille, France)

8.30 – 9.00

Educational – Non-ambiguous characterization of reactive free radicals with EPR

Michael Davies (Copenhagen, Denmark)

9.00 – 9.30

Plenary - Redox-crippled antioxidants in oxidative research: Disrupting the paradigm?

Balaraman Kalyanaraman (Milwaukee, USA)

9.30 – 9.50

Using EPR for assessing particle reactivity and hazard identification of food-grade titanium dioxide (E171) in the human gastro-intestinal tract

Jacco Briede (Maastricht, The Netherlands)

9.50 – 10.10

The exposure of human hepatocytes to SDHIs and strobilurins fungicides alters their mitochondrial function

Barbara Mathieu (Brussels, Belgium)

10.10 – 10.30

EPR-based diagnostic assay CMA reveals multifunctional activities of dietary supplement in subjects recovering from moderate COVID-19. A randomized, double-blind clinical study using Vitamin C as a positive control.

Bruno Finck (Elzach, Germany)

10.30 – 11.00

Coffee break

11.00 – 12.10

Session 11: Data processing

 Chair: Yves-Michel Frapart (Paris, France)

11.00 – 11.30

Plenary - Achievement of biologic endpoints as validation of EPR pO2 images with standard and novel reconstruction algorithms

Howard Halpern (Chicago, USA)

11.30 – 11.50

Optimizing EPR quantification: A Lorentz model for overmodulated single-line EPR spectra

Sébastien Li-Thiao-Té (Paris, France)

11.50 – 12.10

Multiple sources EPR imaging using total variation

Medhi Bousâa (Paris, France)

12.10 – 14.00

Lunch

14.00 – 15.30

Poster session

Even numbers

15.30 – 16.00

Coffee break

16.00 – 17.40

Session 12: Dosimetry / Astrobiology

 Chair: Harold M. Swartz (Hanover, USA)

16.00 – 16.30

Plenary - Virtues of low and high frequencies for EPR dosimetry

François Trompier (Fontenay-aux-Roses, France)

16.30 – 16.50

Impact of bone turnover on the bone dose estimation over time for over exposures at low energy X-rays in mice

Manon Guillou (Fontenay-aux-Roses, France)

16.50 – 17.10

Estimation of accidental radiation exposure by EPR in smartphone screens

Mahinour Mobasher (Fontenay-aux-Roses, France)

17.10 – 17.40

Plenary - What can we learn from EPR about primitive life and its origin on Earth ?

Didier Gourier (Paris, France)

8.00 – 9.40

Session 13: Technology and Instrumentation

 Chair: Hiroshi Hirata (Sapporo, Japan)

8.00 – 8.30

Educational – Rapid Scan EPR: principles, instrumentation, and applications

Mark Tseytlin (Morgantown, USA)

8.30 – 9.00

Educational - Instrumentation for and spin dynamics during frequency-swept pulses in EPR

Gunnar Jeschke (Zurich, Switzerland)

9.00 – 9.20

Nondestructive, Longitudinal, 3D Cell Viability Assessment in a Multi-Well Plate System Using EPR Oxygen Imaging

Mrignayani Kotecha (Chicago, USA)

9.20 – 9.40

High sensitivity multiharmonics technique

Mikolaj Baranowski (Poznan, Poland)

9.40 – 10.10

Coffee break

10.10 – 11.20

Session 14: Technology and Instrumentation (continued)

 Chair: Gunnar Jeschke (Zurich, Switzerland)

10.10 – 10.40

Plenary - Technological advances in resonators for in vivo and clinical EPR

Hiroshi Hirata (Sapporo, Japan)

10.40 – 11.00

Background removal from rapid-scan EPR spectra of nitroxide-based spin labels by minimizing non-quadratic cost functions

Florian Johannsen (Konstanz, Germany)

11.00 – 11.20

Longitudinal RS EPR oxygen imaging of bioprinted constructs

Ryan O'Connell (Morgantown, USA)

11.20 – 11.40

Awards – Final words

11.40

Adjournment